2134/11378460.v1
Thomas Norris
Thomas
Norris
Sarah Crozier
Sarah
Crozier
Noel Cameron
Noel
Cameron
Keith Godfrey
Keith
Godfrey
Hazel Inskip
Hazel
Inskip
Will Johnson
Will
Johnson
Fetal growth does not modify the relationship of infant weight gain with childhood adiposity and blood pressure in the Southampton women’s survey
Loughborough University
2019
Anatomy & Morphology
Biochemistry and Cell Biology
estimated fetal weight
infant weight gain
childhood
adiposity
blood pressure
2019-12-17 09:49:07
Journal contribution
https://repository.lboro.ac.uk/articles/journal_contribution/Fetal_growth_does_not_modify_the_relationship_of_infant_weight_gain_with_childhood_adiposity_and_blood_pressure_in_the_Southampton_women_s_survey/11378460
<p></p><p><b>Background</b>: Rapid infant weight gain is a risk factor for childhood obesity. This
relationship may depend on whether infant weight gain is preceded by in-utero
growth restriction.</p>
<p><b>Aim</b>: Examine whether fetal growth modifies the relationship between infant
weight gain and childhood adiposity and blood pressure.</p>
<p><b>Subjects and methods</b>: 786 children in the Southampton Women’s Survey.
We related infant weight gain (weight at 2 years-birth weight) to body mass
index (BMI), %body fat, trunk fat (kg), systolic (SBP) and diastolic blood
pressure (DBP) at age 6-7 years. Mean estimated fetal weight (EFW) between
19-34 weeks and change in EFW (19-34 weeks) were added to models as effect
modifiers.</p>
<p><b>Results</b>: Infant weight gain was positively associated with all childhood
outcomes. We found no evidence that these effects were modified by fetal growth
(p>0.1 for all interaction terms). For example, a 1 standard deviation (SD)
increase in infant weight gain was associated with an increase in BMI z-score
of 0.51 (95% CI 0.37;0.64) when EFW-change was set at -2 SD-scores compared
with an increase of 0.41 (95% CI 0.27;0.54,p<sub>(interaction)</sub>=0.48) when
set at 2 SD-scores.</p>
<p><b>Conclusion</b>: The documented adverse consequences of rapid infant weight gain may
occur regardless of whether growth was constrained in-utero.</p><br><p></p>