2134/11663838.v1 Adam Causer Adam Causer Janis Shute Janis Shute Michael Cummings Michael Cummings Anthony Shepherd Anthony Shepherd Mathieu Gruet Mathieu Gruet Joseph Costello Joseph Costello Stephen Bailey Stephen Bailey Martin Lindley Martin Lindley Clare Pearson Clare Pearson Gary Connett Gary Connett Mark Allenby Mark Allenby Mary Carroll Mary Carroll Thomas Daniels Thomas Daniels Zoe Saynor Zoe Saynor Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis Loughborough University 2020 Biological markers Glutathione Minerals Oxidoreductases Redox imbalance Respiratory disease Vitamins 2020-01-23 14:29:14 Journal contribution https://repository.lboro.ac.uk/articles/journal_contribution/Circulating_biomarkers_of_antioxidant_status_and_oxidative_stress_in_people_with_cystic_fibrosis_a_systematic_review_and_meta-analysis/11663838 <div>Introduction: Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances. </div><div>Methods: Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI). </div><div>Results: Forty-nine studies were eligible for this review including a total of 1,792 people with CF and 1,675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: -0.66, 95% CI -1.14 to -0.17) and E (SMD: -0.74, 95% CI: -1.28 to -0.20), β-carotene (SMD: -1.80, 95% CI: -2.92 to -0.67), lutein (SMD: -1.52, 95% CI: -1.83 to -1.20) and albumin (SMD: -0.98, 95% CI: -1.68 to -0.27) were significantly lower in the plasma or serum of people with CF versus controls.</div><div>Conclusions: This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.</div>