2134/11663838.v1
Adam Causer
Adam
Causer
Janis Shute
Janis
Shute
Michael Cummings
Michael
Cummings
Anthony Shepherd
Anthony
Shepherd
Mathieu Gruet
Mathieu
Gruet
Joseph Costello
Joseph
Costello
Stephen Bailey
Stephen
Bailey
Martin Lindley
Martin
Lindley
Clare Pearson
Clare
Pearson
Gary Connett
Gary
Connett
Mark Allenby
Mark
Allenby
Mary Carroll
Mary
Carroll
Thomas Daniels
Thomas
Daniels
Zoe Saynor
Zoe
Saynor
Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis
Loughborough University
2020
Biological markers
Glutathione
Minerals
Oxidoreductases
Redox imbalance
Respiratory disease
Vitamins
2020-01-23 14:29:14
Journal contribution
https://repository.lboro.ac.uk/articles/journal_contribution/Circulating_biomarkers_of_antioxidant_status_and_oxidative_stress_in_people_with_cystic_fibrosis_a_systematic_review_and_meta-analysis/11663838
<div>Introduction: Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances. </div><div>Methods: Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI). </div><div>Results: Forty-nine studies were eligible for this review including a total of 1,792 people with CF and 1,675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: -0.66, 95% CI -1.14 to -0.17) and E (SMD: -0.74, 95% CI: -1.28 to -0.20), β-carotene (SMD: -1.80, 95% CI: -2.92 to -0.67), lutein (SMD: -1.52, 95% CI: -1.83 to -1.20) and albumin (SMD: -0.98, 95% CI: -1.68 to -0.27) were significantly lower in the plasma or serum of people with CF versus controls.</div><div>Conclusions: This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.</div>