2134/12328238.v1
Yasuaki Fukazawa
Yasuaki
Fukazawa
Aleksandr E Rubtsov
Aleksandr E
Rubtsov
Andrei Malkov
Andrei
Malkov
A mild method for electrochemical reduction of Heterocyclic N-Oxides
Loughborough University
2020
Nitrogen heterocycles
Reduction
Electrochemistry
N ligands
Synthetic methods
Science & Technology
Physical Sciences
Chemistry, Organic
Chemistry
CHIRAL 2,2'-BIPYRIDINES
DEOXYGENATION
LIGANDS
OXIDATION
Organic Chemistry
Medicinal and Biomolecular Chemistry
Organic Chemistry
2020-05-20 13:09:55
Journal contribution
https://repository.lboro.ac.uk/articles/journal_contribution/A_mild_method_for_electrochemical_reduction_of_Heterocyclic_N-Oxides/12328238
Deoxygenation of heteroaromatic N-oxides is commonly accomplished using chemical or enzymatic methods. In this work, we report on an expedient protocol for electrochemical reduction of pyridine N-oxide derivatives under mild conditions. A diverse range of mono- and bis-N-oxides were converted into the corresponding nitrogen bases in good yields. Importantly, the method is highly selective towards N-oxides and tolerates challenging halo and nitro substituents in the heteroaromatic ring.