2134/12328238.v1 Yasuaki Fukazawa Yasuaki Fukazawa Aleksandr E Rubtsov Aleksandr E Rubtsov Andrei Malkov Andrei Malkov A mild method for electrochemical reduction of Heterocyclic N-Oxides Loughborough University 2020 Nitrogen heterocycles Reduction Electrochemistry N ligands Synthetic methods Science & Technology Physical Sciences Chemistry, Organic Chemistry CHIRAL 2,2'-BIPYRIDINES DEOXYGENATION LIGANDS OXIDATION Organic Chemistry Medicinal and Biomolecular Chemistry Organic Chemistry 2020-05-20 13:09:55 Journal contribution https://repository.lboro.ac.uk/articles/journal_contribution/A_mild_method_for_electrochemical_reduction_of_Heterocyclic_N-Oxides/12328238 Deoxygenation of heteroaromatic N-oxides is commonly accomplished using chemical or enzymatic methods. In this work, we report on an expedient protocol for electrochemical reduction of pyridine N-oxide derivatives under mild conditions. A diverse range of mono- and bis-N-oxides were converted into the corresponding nitrogen bases in good yields. Importantly, the method is highly selective towards N-oxides and tolerates challenging halo and nitro substituents in the heteroaromatic ring.