%0 Journal Article %A Powell, Keddon %A Croker, D.M. %A Rielly, Chris %A Nagy, Zoltan %D 2016 %T PAT-based design of agrochemical co-crystallization processes: a case-study for the selective crystallization of 1:1 and 3:2 co-crystals of p-toluenesulfonamide/triphenylphosphine oxide %U https://repository.lboro.ac.uk/articles/journal_contribution/PAT-based_design_of_agrochemical_co-crystallization_processes_a_case-study_for_the_selective_crystallization_of_1_1_and_3_2_co-crystals_of_p-toluenesulfonamide_triphenylphosphine_oxide/9224048 %2 https://repository.lboro.ac.uk/ndownloader/files/16803533 %K untagged %K Mechanical Engineering %K Engineering not elsewhere classified %X In this study, the selective crystallization and characterization of the stoichiometric forms of the p-toluenesulfonamide/triphenylphosphine oxide (p-TSA-TPPO) co-crystal system in acetonitrile (MeCN) is demonstrated using batch and semi-batch crystallizers. In the batch study, both 1:1 and 3:2 p-TSA-TPPO were successfully isolated as pure forms. However, process variability was observed in a few experimental runs. To address the batch process variability issue, a control strategy was implemented using temperature cycling, aided by in situ process analytical technologies (PAT) to convert from 3:2 to 1:1 p-TSA-TPPO. In the semi-batch co-crystallization studies, the two molecular co-formers, p-TSA and TPPO, were dissolved in MeCN and pumped separately to the crystallizer. Changing the flow rates of the respective active ingredients allowed control over the co-crystallization outcome, and presents as a promising opportunity for development of a continuous co-crystallization process. %I Loughborough University