End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation Salvatore Mascia Patrick L. Heider Haitao Zhang Richard Lakerveld Brahim Benyahia Paul I. Barton Richard D. Braatz Charles L. Cooney James M.B. Evans Timothy F. Jamison Klavs F. Jensen Allan S. Myerson Bernhardt L. Trout 2134/15287 https://repository.lboro.ac.uk/articles/journal_contribution/End-to-end_continuous_manufacturing_of_pharmaceuticals_integrated_synthesis_purification_and_final_dosage_formation/9240155 A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system. 2014-07-22 11:38:50 Continuous processing Flow chemistry Lactones Protecting groups Synthetic methods Chemical Engineering not elsewhere classified