End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation
Salvatore Mascia
Patrick L. Heider
Haitao Zhang
Richard Lakerveld
Brahim Benyahia
Paul I. Barton
Richard D. Braatz
Charles L. Cooney
James M.B. Evans
Timothy F. Jamison
Klavs F. Jensen
Allan S. Myerson
Bernhardt L. Trout
2134/15287
https://repository.lboro.ac.uk/articles/journal_contribution/End-to-end_continuous_manufacturing_of_pharmaceuticals_integrated_synthesis_purification_and_final_dosage_formation/9240155
A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.
2014-07-22 11:38:50
Continuous processing
Flow chemistry
Lactones
Protecting groups
Synthetic methods
Chemical Engineering not elsewhere classified