2134/38374
Goran T. Vladisavljevic
Goran T.
Vladisavljevic
Preparation of microemulsions and nanoemulsions by membrane emulsification
Loughborough University
2019
Membrane
Microemulsion formation
Nanoemulsion formation
Surfactants
Nanoparticles
Drug delivery systems
Chemical Engineering not elsewhere classified
2019-07-22 10:17:15
Journal contribution
https://repository.lboro.ac.uk/articles/journal_contribution/Preparation_of_microemulsions_and_nanoemulsions_by_membrane_emulsification/9240260
This paper is an overview of the applications of microporous membranes for preparation of
micro/nano- emulsions. Membrane emulsification offers compact devices for preparation of
nanoemulsions with low energy consumption, tuneable droplet size, monomodal distribution,
and high encapsulation efficiency of entrapped functional components without shear or thermal
degradation. The properties and wettability modification of Shirasu Porous Glass (SPG)
membrane, track-etched polymeric sheets, syringe filters, anodic alumina membrane, and
nickel-based superalloy membranes were discussed, as well as the design and operation of
membrane devices. Particular emphasis was placed on the effect of formulation, operating
parameters, and membrane properties on the resulting droplet size in direct and premix
membrane emulsification with the examples of nano-sized emulsions produced using different
membranes. The application of microemulsions prepared using synthetic membranes for
production of solid self-microemulsifying drug delivery systems for enhanced solubility and
oral bioavailability of BSC Class II and III drugs was also reviewed, as well as production of
solid nanoparticles such as nanogels, solid lipid nanoparticles, synthetic biodegradable polymer
nanoparticles, silica and metal oxide nanoparticles from nanoemulsion templates prepared by
membrane emulsification.