2134/5651
G. Gasparini
G.
Gasparini
Richard Holdich
Richard
Holdich
S.R. Kosvintsev
S.R.
Kosvintsev
PLGA particle production for water soluble drug encapsulation: degradation and release behaviour
Loughborough University
2009
Membrane emulsification
Diffusion
Surface erosion
Chemical Engineering not elsewhere classified
2009-12-11 14:27:42
Journal contribution
https://repository.lboro.ac.uk/articles/journal_contribution/PLGA_particle_production_for_water_soluble_drug_encapsulation_degradation_and_release_behaviour/9241823
Particles for subcutaneous depot use encapsulating a model water soluble
drug have been produced from poly(lactic-glycolic acid) (PLGA) using a
membrane emulsification – solvent evaporation technique. The release
behaviour, mainly the change in size and inner morphology are reported.
During release, the particles initially swelled in size, then reduced. A diffusion
based model, taking in to account the change in particle size, is presented.
Surface erosion is evident from the particle size and image evidence, and the
diffusion model provides a fit to the data even during the surface erosion
period, suggesting that the model drug diffuses before the particle degrades.