2134/16628
Atul Nayak
Atul
Nayak
Diganta Das
Diganta
Das
Goran Vladisavljevic
Goran
Vladisavljevic
Microneedle-assisted permeation of lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel
Loughborough University
2015
Gelatine
Hydrogel
In vitro skin permeation
Lidocaine
Microneedles
Sodium carboxymethylcellulose
Chemical Engineering not elsewhere classified
2015-01-23 14:45:10
Journal contribution
https://repository.lboro.ac.uk/articles/journal_contribution/Microneedle-assisted_permeation_of_lidocaine_carboxymethylcellulose_with_gelatine_co-polymer_hydrogel/9243116
Purpose Lidocaine hydrochloride (LidH) was formulated in
sodium carboxymethyl cellulose/ gelatine (NaCMC/GEL)
hydrogel and a ‘poke and patch’ microneedle delivery method
was used to enhance permeation flux of LidH.
Methods The microparticles were formed by electrostatic
interactions between NaCMC and GEL macromolecules within
a water/oil emulsion in paraffin oil and the covalent crosslinking
was by glutaraldehyde. The GEL to NaCMC mass ratio was
varied between 1.6 and 2.7. The LidH encapsulation yield was
1.2 to 7% w/w. LidH NaCMC/GEL was assessed for
encapsulation efficiency, zeta potential, mean particle size and
morphology. Subsequent in vitro skin permeation studies were
performed via passive diffusion and microneedle assisted
permeation of LidH NaCMC/GEL to determine the maximum
permeation rate through full thickness skin.
Results LidH 2.4% w/w NaCMC/GEL 1:1.6 and 1:2.3
respectively, possessed optimum zeta potential. LidH 2.4% w/
w NaCMC/GEL 1:2.3 and 1:2.7 demonstrate higher
pseudoplastic behaviour. Encapsulation efficiency (14.9–17.2%)
was similar for LidH 2.4% w/w NaCMC/GEL 1:1.6–1:2.3.
Microneedle assisted permeation flux was optimum for LidH
2.4% w/w NaCMC/GEL 1:2.3 at 6.1 μg/ml/h.
Conclusion LidH 2.4% w/w LidH NaCMC/GEL 1:2.3 crossed
the minimum therapeutic drug threshold with microneedle skin
permeation in less than 70 min.