Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures
Mark Leaper
Kashaf Ali
Andrew J. Ingham
2134/26620
https://repository.lboro.ac.uk/articles/journal_contribution/Comparing_the_dynamic_flow_properties_and_compaction_properties_of_pharmaceutical_powder_mixtures/9244748
The dynamic flow properties and compaction characteristics of mannitol and
mannitol-sodium carbonate mixtures (80/20, 70/30 and 60/40 by mass) were measured
using a Freeman FT4 powder rheometer. The results showed that the mixtures containing
up to 30% sodium carbonate had better flow properties and improved compaction
characteristics when compared with mannitol alone. The study demonstrated the feasibility
of combining a more expensive pharmaceutical excipient with a cheaper ingredient, without
compromising desired powder characteristics. It may also provide a useful method for
assessing the suitability of new formulations for use as direct compression bases, as part of
a wider range of powder flow tests.
2017-09-22 10:49:57
untagged
Mechanical Engineering
Chemical Engineering not elsewhere classified