Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures Mark Leaper Kashaf Ali Andrew J. Ingham 2134/26620 https://repository.lboro.ac.uk/articles/journal_contribution/Comparing_the_dynamic_flow_properties_and_compaction_properties_of_pharmaceutical_powder_mixtures/9244748 The dynamic flow properties and compaction characteristics of mannitol and mannitol-sodium carbonate mixtures (80/20, 70/30 and 60/40 by mass) were measured using a Freeman FT4 powder rheometer. The results showed that the mixtures containing up to 30% sodium carbonate had better flow properties and improved compaction characteristics when compared with mannitol alone. The study demonstrated the feasibility of combining a more expensive pharmaceutical excipient with a cheaper ingredient, without compromising desired powder characteristics. It may also provide a useful method for assessing the suitability of new formulations for use as direct compression bases, as part of a wider range of powder flow tests. 2017-09-22 10:49:57 untagged Mechanical Engineering Chemical Engineering not elsewhere classified