2134/33829 Yulia Timofeeva Yulia Timofeeva Oscillations and waves in single- and multi-cellular systems with free calcium Loughborough University 2018 untagged Mathematical Sciences not elsewhere classified 2018-07-10 10:32:54 Thesis https://repository.lboro.ac.uk/articles/thesis/Oscillations_and_waves_in_single-_and_multi-cellular_systems_with_free_calcium/9375992 Calcium ions are an important second messenger in living cells. Indeed calcium signals in the form of waves have been the subject of much recent experimental interest. A fundamental approach for studying cellular signalling is the combination of state-of-the-art experimental techniques, in particular high-resolution fluorescence imaging, with spatio-temporal mathematical models of intracellular calcium regulation. Experimental findings can be incorporated into mathematical models and, vice versa, model predictions can be directly tested in experiments. This approach provides a powerful tool to clarify the very complex mechanisms involved in cellular Ca2+ signalling. The aim of this thesis is to provide insight into oscillations and waves of cytosolic Ca2+ in both single- and multi-cellular systems from a mathematical perspective. [Continues.]