2134/33829
Yulia Timofeeva
Yulia
Timofeeva
Oscillations and waves in single- and multi-cellular systems with free calcium
Loughborough University
2018
untagged
Mathematical Sciences not elsewhere classified
2018-07-10 10:32:54
Thesis
https://repository.lboro.ac.uk/articles/thesis/Oscillations_and_waves_in_single-_and_multi-cellular_systems_with_free_calcium/9375992
Calcium ions are an important second messenger in living cells. Indeed calcium signals
in the form of waves have been the subject of much recent experimental interest.
A fundamental approach for studying cellular signalling is the combination of state-of-the-art experimental techniques, in particular high-resolution fluorescence imaging,
with spatio-temporal mathematical models of intracellular calcium regulation. Experimental
findings can be incorporated into mathematical models and, vice versa, model
predictions can be directly tested in experiments. This approach provides a powerful
tool to clarify the very complex mechanisms involved in cellular Ca2+ signalling.
The aim of this thesis is to provide insight into oscillations and waves of cytosolic Ca2+
in both single- and multi-cellular systems from a mathematical perspective. [Continues.]