%0 Journal Article %A Feng, Xing %A Li, Ying %A He, Xuewen %A Liu, Haixiang %A Zhao, Zheng %A Kwok, Ryan T. %A Elsegood, Mark %A Lam, Jacky W.Y. %A Tang, Ben Zhong %D 2018 %T A substitution-dependent light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application %U https://repository.lboro.ac.uk/articles/journal_contribution/A_substitution-dependent_light-up_fluorescence_probe_for_selectively_detecting_Fe3_ions_and_its_cell_imaging_application/9389963 %2 https://repository.lboro.ac.uk/ndownloader/files/17003375 %K Acid dissociation constant %K Aggregation‐induced emission %K Cell imaging %K Iron (III) %K Molecular recognition %K Chemical Sciences not elsewhere classified %X Deliberate design of specific and sensitive molecular probes with distinctive physical/chemical properties for analyte sensing is of great significance. Herein, by taking advantage of the position-dependent substituent effects, an aggregation-induced emission featured iron (III) probe from ortho-substituted pyridinyl-functionalized tetraphenylethylene (TPE-o-Py) is synthesized. It displays high sensitivity and selectivity toward iron (III) detection. The recognition arises from the position isomer of ortho-substitution, and the fact that TPE-o-Py has a low acid dissociation constant (pKa) that is close to that of hydrolyzed Fe3+. Importantly, TPE-o-Py as a light-up fluorescence probe could be employed for Fe3+sensing in living cells with a pronounced red-shift in fluorescence emission. %I Loughborough University