The selective mono and difunctionalization of carbocyclic cleft molecules with pyridyl groups and X-ray crystallographic analysis Priti Jilka Claire Millington Mark Elsegood Josef W.A. Frese Simon J. Teat Marc Kimber 2134/13949 https://repository.lboro.ac.uk/articles/journal_contribution/The_selective_mono_and_difunctionalization_of_carbocyclic_cleft_molecules_with_pyridyl_groups_and_X-ray_crystallographic_analysis/9390692 The diesterification and selective mono and dialkylation of carbocyclic analogues of Tröger’s base with pyridyl groups has been achieved in high yield and good selectivity giving access to a novel range of cleft molecules capable of binding events. Reaction conditions for the selective functionalization of this carbocyclic cleft molecule are discussed as well as the solid state structures of these newly synthesized ligands. 2014-01-10 14:32:04 Carbocyclic cleft Chiral cavity Alkylation Esterification Recognition Chemical Sciences not elsewhere classified Organic Chemistry