The selective mono and difunctionalization of carbocyclic cleft molecules with pyridyl groups and X-ray crystallographic analysis
Priti Jilka
Claire Millington
Mark Elsegood
Josef W.A. Frese
Simon J. Teat
Marc Kimber
2134/13949
https://repository.lboro.ac.uk/articles/journal_contribution/The_selective_mono_and_difunctionalization_of_carbocyclic_cleft_molecules_with_pyridyl_groups_and_X-ray_crystallographic_analysis/9390692
The diesterification and selective mono and dialkylation of carbocyclic analogues of Tröger’s base with pyridyl groups has been achieved in high yield and good selectivity giving access to a novel range of cleft molecules capable of binding events. Reaction conditions for the selective functionalization of this carbocyclic cleft molecule are discussed as well as the solid state structures of these newly synthesized ligands.
2014-01-10 14:32:04
Carbocyclic cleft
Chiral cavity
Alkylation
Esterification
Recognition
Chemical Sciences not elsewhere classified
Organic Chemistry