2134/13937
Alexandra E. Horton
Alexandra E.
Horton
Oliver S. May
Oliver S.
May
Mark Elsegood
Mark
Elsegood
Marc Kimber
Marc
Kimber
Total synthesis of the marine-derived cyclic depsipeptide alternaramide
Loughborough University
2014
Natural product
Depsipeptide
Peptide coupling
Macrolactonization
Macrolactamization
Chemical Sciences not elsewhere classified
Organic Chemistry
2014-01-09 15:14:15
Journal contribution
https://repository.lboro.ac.uk/articles/journal_contribution/Total_synthesis_of_the_marine-derived_cyclic_depsipeptide_alternaramide/9391703
The first synthesis of the marine fungus derived natural product alternaramide is described using solution phase coupling protocols and via a macrolactonization and macrolactamization route. The structure of alternaramide was confirmed and was supported by single crystal X-ray analysis which exhibited three similar molecules in the asymmetric unit, each with transannular hydrogen bonds.