2134/13937 Alexandra E. Horton Alexandra E. Horton Oliver S. May Oliver S. May Mark Elsegood Mark Elsegood Marc Kimber Marc Kimber Total synthesis of the marine-derived cyclic depsipeptide alternaramide Loughborough University 2014 Natural product Depsipeptide Peptide coupling Macrolactonization Macrolactamization Chemical Sciences not elsewhere classified Organic Chemistry 2014-01-09 15:14:15 Journal contribution https://repository.lboro.ac.uk/articles/journal_contribution/Total_synthesis_of_the_marine-derived_cyclic_depsipeptide_alternaramide/9391703 The first synthesis of the marine fungus derived natural product alternaramide is described using solution phase coupling protocols and via a macrolactonization and macrolactamization route. The structure of alternaramide was confirmed and was supported by single crystal X-ray analysis which exhibited three similar molecules in the asymmetric unit, each with transannular hydrogen bonds.