2134/25266
Robert Lee
Robert
Lee
Martin Lindley
Martin
Lindley
Gareth Pritchard
Gareth
Pritchard
Marc Kimber
Marc
Kimber
A biosynthetically inspired route to substituted furans using the Appel reaction: total synthesis of the furan fatty acid F<sub>5</sub>
Loughborough University
2017
untagged
Chemical Sciences not elsewhere classified
2017-06-06 13:50:37
Journal contribution
https://repository.lboro.ac.uk/articles/journal_contribution/A_biosynthetically_inspired_route_to_substituted_furans_using_the_Appel_reaction_total_synthesis_of_the_furan_fatty_acid_F_sub_5_sub_/9392678
Appel reaction conditions have been harnessed to affect a mild biosynthetically inspired dehydration of endoperoxides to deliver multi-substituted electron rich furans. Unlike traditional dehydrative procedures, this method is metal and acid free, and can be achieved under redox neutral conditions. It is general for a range of aryl and alkyl substituted endoperoxides, and is functional group tolerant. Furthermore, this procedure has been used to deliver an effective total synthesis of the furan fatty acid (FFA) F5.