2134/25266 Robert Lee Robert Lee Martin Lindley Martin Lindley Gareth Pritchard Gareth Pritchard Marc Kimber Marc Kimber A biosynthetically inspired route to substituted furans using the Appel reaction: total synthesis of the furan fatty acid F<sub>5</sub> Loughborough University 2017 untagged Chemical Sciences not elsewhere classified 2017-06-06 13:50:37 Journal contribution https://repository.lboro.ac.uk/articles/journal_contribution/A_biosynthetically_inspired_route_to_substituted_furans_using_the_Appel_reaction_total_synthesis_of_the_furan_fatty_acid_F_sub_5_sub_/9392678 Appel reaction conditions have been harnessed to affect a mild biosynthetically inspired dehydration of endoperoxides to deliver multi-substituted electron rich furans. Unlike traditional dehydrative procedures, this method is metal and acid free, and can be achieved under redox neutral conditions. It is general for a range of aryl and alkyl substituted endoperoxides, and is functional group tolerant. Furthermore, this procedure has been used to deliver an effective total synthesis of the furan fatty acid (FFA) F5.