EuroTracker (R) dyes: design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging
Stephen Butler
Martina Delbianco
Laurent Lamarque
Brian K. McMahon
Emily R. Neil
Robert Pal
David Parker
James W. Walton
Jurriaan M. Zwier
2134/18759
https://repository.lboro.ac.uk/articles/journal_contribution/EuroTracker_R_dyes_design_synthesis_structure_and_photophysical_properties_of_very_bright_europium_complexes_and_their_use_in_bioassays_and_cellular_optical_imaging/9394178
The development of the brightest luminescent europium(III) complexes is traced, including analysis of
the C3-symmetric core complex based on a functionalized triazacyclononane and identification of the
most suitable strongly absorbing chromophore. Strategies for the synthesis of the complexes, including
enantiopure analogues, are outlined and opportunities for applications in time-resolved microscopy and
spectral imaging emphasised. Practicable examples are introduced, including selective organelle staining
for cellular optical imaging at 65 nm resolution and the development of new bioassays using time resolved
FRET methods.
2015-09-15 13:05:07
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Chemical Sciences not elsewhere classified
Inorganic Chemistry