2134/11483 P. Mark Jackson P. Mark Jackson Christopher J. Moody Christopher J. Moody Roger J. Mortimer Roger J. Mortimer Synthesis and electrochemical properties of the naturally occurring free radical scavenger carazostatin Loughborough University 2013 untagged Chemical Sciences not elsewhere classified 2013-01-17 14:43:41 Journal contribution https://repository.lboro.ac.uk/articles/journal_contribution/Synthesis_and_electrochemical_properties_of_the_naturally_occurring_free_radical_scavenger_carazostatin/9394775 A short synthesis of the naturally occurring free radical scavenger carazostatin 1 starting from indol-3-ylacetic acid is described, the key step being the regiospecific Diels–Alder reaction of the indolopyrone 2 with ethyl trimethylsilylpropynoate. Electrochemical studies on carazostatin and some of its derivatives show it to be more easily oxidised than butylated hydroxytoluene (BHT).