Highly enantio- and diastereoselective generation of two quaternary centers in spirocyclopropanation of oxindole derivatives Artur Noole Natalia S. Sucman Mikhail A. Kabeshov Tonis Kanger Fliur Z. Macaev Andrei Malkov 2134/15479 https://repository.lboro.ac.uk/articles/journal_contribution/Highly_enantio-_and_diastereoselective_generation_of_two_quaternary_centers_in_spirocyclopropanation_of_oxindole_derivatives/9394931 Spirocyclopropanes: only one out of eight possible stereoisomers was obtained in the asymmetric cascade cyclopropanation of alkylidene oxindoles with ethyl 2-chloroacetoacetate. Improved catalyst design ensured that spirocyclopropyl oxindoles featuring two quaternary centers were synthesized in high yield and high enantio-and diastereoselectivity. 2014-08-08 15:07:18 Catalysis Asymmetric catalysis Cascade reactions Cyclization Organocatalysis Spiro compounds Chemical Sciences not elsewhere classified