A novel bifunctional allyldisilane as a triple allylation reagent in the stereoselective synthesis of trisubstituted tetrahydrofurans Andrei Malkov Ondrej Kysilka Mark Edgar Aneta Kadlcikova Martin Kotora Pavel Kocovsky 2134/13545 https://repository.lboro.ac.uk/articles/journal_contribution/A_novel_bifunctional_allyldisilane_as_a_triple_allylation_reagent_in_the_stereoselective_synthesis_of_trisubstituted_tetrahydrofurans/9395759 Three for the price of two: A bifunctional allyldisilane undergoes a two-step triple allylation sequence with pairs of aldehydes to give all-cis trisubstituted tetrahydrofurans in excellent enantio- and diastereoselectivity (see scheme). The first allylation step, which sets up the key stereogenic centres, is catalysed by a chiral Lewis base. 2013-11-12 14:27:15 Allylation Asymmetric catalysis Rearrangement Silanes Stereoselectivity Chemical Sciences not elsewhere classified