Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry Robert W. Smith Jim Reynolds Sze-Ling Lee Colin Creaser 2134/13847 https://repository.lboro.ac.uk/articles/journal_contribution/Direct_analysis_of_potentially_genotoxic_impurities_by_thermal_desorption-field_asymmetric_waveform_ion_mobility_spectrometry-mass_spectrometry/9395855 Thermal desorption has been combined with field asymmetric waveform ion mobility spectrometry and mass spectrometry for the rapid, direct analysis of isobaric potentially genotoxic impurities (PGIs) in a surrogate active pharmaceutical ingredient. FAIMSselected PGIs were detected with limits of quantification <0.2 ppm, below the threshold of toxicological concern, with %RSD <8.4%, at the 1 ppm level. 2013-12-17 11:46:35 untagged Chemical Sciences not elsewhere classified