The synthesis of novel agents which inhibit tumour-stimulated bone resorption Ian D. Mansfield 2134/27412 https://repository.lboro.ac.uk/articles/thesis/The_synthesis_of_novel_agents_which_inhibit_tumour-stimulated_bone_resorption/9396818 A range of conjugates which focused on bisphosphonates as delivery molecules and on oestrogens as resorption inhibitors were synthesised. Various moieties were coupled through an ester linkage to bisphosphonates which were then converted to the corresponding bisphosphonic acids. This ester linkage was considered to be readily hydrolysable under normal physiological conditions. [Continues.] 2017-11-14 17:22:22 untagged Chemical Sciences not elsewhere classified