Triorganogermanes as non-toxic reagents in radical reactions
Sussie L. Krintel
2134/35978
https://repository.lboro.ac.uk/articles/thesis/Triorganogermanes_as_non-toxic_reagents_in_radical_reactions/9399035
Tributyltin hydride (TBTH) has proven to be an extremely useful synthetic reagent
which has been widely used for generating free radicals, is largely responsible for the
large increase in the use of free radicals in organic synthesis and is the reagent of
choice for many researchers. However, the tin residues are highly toxic and difficult to
separate from reaction mixtures which precludes the use of tributyltin hydride in the
pharmaceutical industry. In this project, triorganogermanium compounds have been
investigated as possible alternatives to tin-based radical mediators. [Continues.]
2018-11-14 16:38:10
untagged
Chemical Sciences not elsewhere classified