2134/22226 Yuanyuan Cai Yuanyuan Cai Yihong Qiu Yihong Qiu Lan Wei Lan Wei Wei Zhang Wei Zhang Sijung Hu Sijung Hu Peter R. Smith Peter R. Smith Vincent P. Crabtree Vincent P. Crabtree Shanbao Tong Shanbao Tong Nitish V. Thakor Nitish V. Thakor Yisheng Zhu Yisheng Zhu Complex character analysis of heart rate variability following brain asphyxia Loughborough University 2016 Brain asphyxia Heart rate variability Renyi entropy L–Z complexity Mechanical Engineering not elsewhere classified 2016-08-08 08:28:21 Journal contribution https://repository.lboro.ac.uk/articles/journal_contribution/Complex_character_analysis_of_heart_rate_variability_following_brain_asphyxia/9545420 In the present study Renyi entropy and L–Z complexity were used to characterize heart rate variability (HRV) of rats that were suffered from brain asphyxia and ischemia. Two groups of rats were studied: (a) rats (n = 5) injected with NAALADase inhibitor, 2-PMPA, which has been proven neuroprotective in asphyxia injury and (b) control subjects (n = 5) without medication. Renyi entropy and L–Z complexity of the R–R intervals (RRI) at different experiment stages were investigated in the two groups. The results show that both measures indicate less injury and better recovery in the drug injection group. The dynamic change of 90 min RRI signal after the asphyxia was investigated. The sudden reduction of the two parameters shows their sensitivity to the asphyxia insult.