2134/22226
Yuanyuan Cai
Yuanyuan
Cai
Yihong Qiu
Yihong
Qiu
Lan Wei
Lan
Wei
Wei Zhang
Wei
Zhang
Sijung Hu
Sijung
Hu
Peter R. Smith
Peter R.
Smith
Vincent P. Crabtree
Vincent P.
Crabtree
Shanbao Tong
Shanbao
Tong
Nitish V. Thakor
Nitish V.
Thakor
Yisheng Zhu
Yisheng
Zhu
Complex character analysis of heart rate variability following brain asphyxia
Loughborough University
2016
Brain asphyxia
Heart rate variability
Renyi entropy
L–Z complexity
Mechanical Engineering not elsewhere classified
2016-08-08 08:28:21
Journal contribution
https://repository.lboro.ac.uk/articles/journal_contribution/Complex_character_analysis_of_heart_rate_variability_following_brain_asphyxia/9545420
In the present study Renyi entropy and L–Z complexity were used to characterize heart rate variability (HRV) of rats that were suffered from brain asphyxia and ischemia. Two groups of rats were studied: (a) rats (n = 5) injected with NAALADase inhibitor, 2-PMPA, which has been proven neuroprotective in asphyxia injury and (b) control subjects (n = 5) without medication. Renyi entropy and L–Z complexity of the R–R intervals (RRI) at different experiment stages were investigated in the two groups. The results show that both measures indicate less injury and better recovery in the drug injection group. The dynamic change of 90 min RRI signal after the asphyxia was investigated. The sudden reduction of the two parameters shows their sensitivity to the asphyxia insult.