2134/20846
Maurice Dungey
Maurice
Dungey
Nicolette Bishop
Nicolette
Bishop
Hannah M.L. Young
Hannah M.L.
Young
James O. Burton
James O.
Burton
Alice C. Smith
Alice C.
Smith
The impact of exercising during haemodialysis on blood pressure, markers of cardiac injury and systemic inflammation - preliminary results of a pilot study
Loughborough University
2016
Blood pressure
Cardiovascular disease
Exercise
Haemodialysis
Inflammation
Medical and Health Sciences not elsewhere classified
2016-04-08 09:04:53
Journal contribution
https://repository.lboro.ac.uk/articles/journal_contribution/The_impact_of_exercising_during_haemodialysis_on_blood_pressure_markers_of_cardiac_injury_and_systemic_inflammation_-_preliminary_results_of_a_pilot_study/9617192
Background/Aims: Patients requiring haemodialysis have cardiovascular and immune
dysfunction. Little is known about the acute effects of exercise during haemodialysis. Exercise
has numerous health benefits but in other populations has a profound impact upon blood
pressure, inflammation and immune function; therefore having the potential to exacerbate
cardiovascular and immune dysfunction in this vulnerable population. Methods: Fifteen
patients took part in a randomised-crossover study investigating the effect of a 30-min
bout of exercise during haemodialysis compared to resting haemodialysis. We assessed
blood pressure, plasma markers of cardiac injury and systemic inflammation and neutrophil
degranulation. Results: Exercise increased blood pressure immediately post-exercise; however,
1 hour after exercise blood pressure was lower than resting levels (106±22 vs. 117±25 mm
Hg). No differences in h-FABP, cTnI, myoglobin or CKMB were observed between trial arms.
Exercise did not alter circulating concentrations of IL-6, TNF-α or IL-1ra nor clearly suppress
neutrophil function. Conclusions: This study demonstrates fluctuations in blood pressure
during haemodialysis in response to exercise. However, since the fall in blood pressure
occurred without evidence of cardiac injury, we regard it as a normal response to exercise
superimposed onto the haemodynamic response to haemodialysis. Importantly, exercise did
not exacerbate systemic inflammation or immune dysfunction; intradialytic exercise was well
tolerated.