%0 Journal Article %A Dungey, Maurice %A Bishop, Nicolette %A Young, Hannah M.L. %A Burton, James O. %A Smith, Alice C. %D 2016 %T The impact of exercising during haemodialysis on blood pressure, markers of cardiac injury and systemic inflammation - preliminary results of a pilot study %U https://repository.lboro.ac.uk/articles/journal_contribution/The_impact_of_exercising_during_haemodialysis_on_blood_pressure_markers_of_cardiac_injury_and_systemic_inflammation_-_preliminary_results_of_a_pilot_study/9617192 %2 https://repository.lboro.ac.uk/ndownloader/files/17264855 %K Blood pressure %K Cardiovascular disease %K Exercise %K Haemodialysis %K Inflammation %K Medical and Health Sciences not elsewhere classified %X Background/Aims: Patients requiring haemodialysis have cardiovascular and immune dysfunction. Little is known about the acute effects of exercise during haemodialysis. Exercise has numerous health benefits but in other populations has a profound impact upon blood pressure, inflammation and immune function; therefore having the potential to exacerbate cardiovascular and immune dysfunction in this vulnerable population. Methods: Fifteen patients took part in a randomised-crossover study investigating the effect of a 30-min bout of exercise during haemodialysis compared to resting haemodialysis. We assessed blood pressure, plasma markers of cardiac injury and systemic inflammation and neutrophil degranulation. Results: Exercise increased blood pressure immediately post-exercise; however, 1 hour after exercise blood pressure was lower than resting levels (106±22 vs. 117±25 mm Hg). No differences in h-FABP, cTnI, myoglobin or CKMB were observed between trial arms. Exercise did not alter circulating concentrations of IL-6, TNF-α or IL-1ra nor clearly suppress neutrophil function. Conclusions: This study demonstrates fluctuations in blood pressure during haemodialysis in response to exercise. However, since the fall in blood pressure occurred without evidence of cardiac injury, we regard it as a normal response to exercise superimposed onto the haemodynamic response to haemodialysis. Importantly, exercise did not exacerbate systemic inflammation or immune dysfunction; intradialytic exercise was well tolerated. %I Loughborough University