%0 Journal Article %A Clayton, David J. %A Biddle, Stuart J.H. %A Maher, Tyler %A Funnell, Mark P. %A Sargeant, Jack %A King, James %A Hulston, Carl %A Stensel, David %A James, Lewis %D 2018 %T 24 h severe energy restriction impairs post-prandial glycaemic control in young, lean males %U https://repository.lboro.ac.uk/articles/journal_contribution/24_h_severe_energy_restriction_impairs_post-prandial_glycaemic_control_in_young_lean_males/9619088 %2 https://repository.lboro.ac.uk/ndownloader/files/17266784 %K Intermittent energy restriction %K Intermittent fasting %K Insulin sensitivity %K Type-2 diabetes %K Weight management %K Medical and Health Sciences not elsewhere classified %X Intermittent energy restriction (IER) involves short periods of severe energy restriction interspersed with periods of adequate energy intake, and can induce weight loss. Insulin sensitivity is impaired by short-term, complete energy restriction, but the effects of IER are not well known. In randomised order, 14 lean men (age: 25 (SD 4) y; BMI: 24 (SD 2) kg·m-2; body fat: 17 (4) %) consumed 24 h diets providing 100% (10441 (SD 812) kJ; EB) or 25% (2622 (SD 204) kJ; ER) of estimated energy requirements, followed by an oral glucose tolerance test (OGTT; 75g glucose drink) overnight fasted. Plasma/ serum glucose, insulin, non-esterified fatty acids (NEFA), glucagon-like peptide-1 (GLP-1), glucose-dependant insulinotropic peptide (GIP) and fibroblast growth factor-21 (FGF21) were assessed before and after (0 h) each 24 h dietary intervention, and throughout the 2 h OGTT. Homeostatic model assessment of insulin resistance (HOMA2-IR) assessed the fasted response and incremental (iAUC) or total (tAUC) area under the curve were calculated during the OGTT. At 0 h, HOMA2-IR was 23% lower after ER compared to EB (P<0.05). During the OGTT, serum glucose iAUC (P<0.001) serum insulin iAUC (P<0.05) and plasma NEFA tAUC (P<0.01) were greater during ER, but GLP-1 (P=0.161), GIP (P=0.473) and FGF21 (P=0.497) tAUC were similar between trials. These results demonstrate that severe energy restriction acutely impairs postprandial glycaemic control in lean men, despite reducing HOMA2-IR. Chronic intervention studies are required to elucidate the long-term effects of IER on indices of insulin sensitivity, particularly in the absence of weight loss. %I Loughborough University