2134/25226
Oonagh Markey
Oonagh
Markey
Dafni Vasilopoulou
Dafni
Vasilopoulou
Kirsty E. Kliem
Kirsty E.
Kliem
Albert Koulman
Albert
Koulman
Colette C. Fagan
Colette C.
Fagan
Keith Summerhill
Keith
Summerhill
Laura Y. Wang
Laura Y.
Wang
Alistair S. Grandison
Alistair S.
Grandison
David J. Humphries
David J.
Humphries
Susan Todd
Susan
Todd
Kim G. Jackson
Kim G.
Jackson
David Ian Givens
David Ian
Givens
Julie A. Lovegrove
Julie A.
Lovegrove
Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial
Loughborough University
2017
Cardiovascular disease
Dairy products
Dietary fat composition
Food-exchange model
Fatty acids
Monounsaturated fatty acids
Nutrition assessment
Phospholipids
Saturated fatty acids
Medical and Health Sciences not elsewhere classified
2017-06-02 09:48:31
Journal contribution
https://repository.lboro.ac.uk/articles/journal_contribution/Plasma_phospholipid_fatty_acid_profile_confirms_compliance_to_a_novel_saturated_fat-reduced_monounsaturated_fat-enriched_dairy_product_intervention_in_adults_at_moderate_cardiovascular_risk_a_randomized_controlled_trial/9619814
Background: Dairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet. To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product consumption in the RESET (REplacement of SaturatEd fat in dairy on Total cholesterol) study using 4-d weighed dietary records, in addition to plasma phospholipid FA (PL-FA) status. Methods: In a randomised, controlled, crossover design, free-living UK participants identified as moderate risk for CVD (n = 54) were required to replace habitually consumed dairy foods (milk, cheese and butter), with study products with a FA profile typical of retail products (control) or SFA-reduced, MUFA-enriched profile (modified), for two 12-week periods, separated by an 8-week washout period. A flexible food-exchange model was used to implement each isoenergetic high-fat, high-dairy diet (38% of total energy intake (%TE) total fat): control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA). Results: Following the modified diet, there was a smaller increase in SFA (17.2%TE vs. 19.1%TE; p < 0.001) and greater increase in MUFA intake (15.4%TE vs. 11.8%TE; p < 0.0001) when compared with the control. PL-FA analysis revealed lower total SFAs (p = 0.006), higher total cis-MUFAs and trans-MUFAs (both p < 0.0001) following the modified diet. Conclusion: The food-exchange model was successfully used to achieve RESET dietary targets by partial replacement of SFAs with MUFAs in dairy products, a finding reflected in the PL-FA profile and indicative of objective dietary compliance.