%0 Journal Article %A Markey, Oonagh %A Vasilopoulou, Dafni %A Kliem, Kirsty E. %A Koulman, Albert %A Fagan, Colette C. %A Summerhill, Keith %A Wang, Laura Y. %A Grandison, Alistair S. %A Humphries, David J. %A Todd, Susan %A Jackson, Kim G. %A Givens, David Ian %A Lovegrove, Julie A. %D 2017 %T Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial %U https://repository.lboro.ac.uk/articles/journal_contribution/Plasma_phospholipid_fatty_acid_profile_confirms_compliance_to_a_novel_saturated_fat-reduced_monounsaturated_fat-enriched_dairy_product_intervention_in_adults_at_moderate_cardiovascular_risk_a_randomized_controlled_trial/9619814 %2 https://repository.lboro.ac.uk/ndownloader/files/17267516 %K Cardiovascular disease %K Dairy products %K Dietary fat composition %K Food-exchange model %K Fatty acids %K Monounsaturated fatty acids %K Nutrition assessment %K Phospholipids %K Saturated fatty acids %K Medical and Health Sciences not elsewhere classified %X Background: Dairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet. To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product consumption in the RESET (REplacement of SaturatEd fat in dairy on Total cholesterol) study using 4-d weighed dietary records, in addition to plasma phospholipid FA (PL-FA) status. Methods: In a randomised, controlled, crossover design, free-living UK participants identified as moderate risk for CVD (n = 54) were required to replace habitually consumed dairy foods (milk, cheese and butter), with study products with a FA profile typical of retail products (control) or SFA-reduced, MUFA-enriched profile (modified), for two 12-week periods, separated by an 8-week washout period. A flexible food-exchange model was used to implement each isoenergetic high-fat, high-dairy diet (38% of total energy intake (%TE) total fat): control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA). Results: Following the modified diet, there was a smaller increase in SFA (17.2%TE vs. 19.1%TE; p < 0.001) and greater increase in MUFA intake (15.4%TE vs. 11.8%TE; p < 0.0001) when compared with the control. PL-FA analysis revealed lower total SFAs (p = 0.006), higher total cis-MUFAs and trans-MUFAs (both p < 0.0001) following the modified diet. Conclusion: The food-exchange model was successfully used to achieve RESET dietary targets by partial replacement of SFAs with MUFAs in dairy products, a finding reflected in the PL-FA profile and indicative of objective dietary compliance. %I Loughborough University