Influence of a fed or fasted state on the s-IgA response to prolonged cycling in active men and women
Judith E. Allgrove
Louise Geneen
Sarah Latif
Michael Gleeson
2134/10573
https://repository.lboro.ac.uk/articles/journal_contribution/Influence_of_a_fed_or_fasted_state_on_the_s-IgA_response_to_prolonged_cycling_in_active_men_and_women/9622343
This study investigated the effect of a fed or fasted state on the salivary immunoglobulin
A (s-IgA) response to prolonged cycling. Using a randomized, crossover
design, 16 active adults (8 men and 8 women) performed 2 hr of cycling on a stationary
ergometer at 65% of maximal oxygen uptake on 1 occasion after an overnight fast
(FAST) and on another occasion 2 hr after consuming a 2.2-MJ high-carbohydrate
meal (FED). Timed, unstimulated whole saliva samples were collected immediately
before ingestion of the meal, immediately preexercise, 5 min before cessation of exercise,
immediately postexercise, and 1 hr postexercise. The samples were analyzed for
s-IgA concentration, osmolality, and cortisol, and saliva flow rates were determined
to calculate s-IgA secretion rate. Saliva flow rate decreased by 50% during exercise (p
< .05), and s-IgA concentration increased by 42% (p < .05), but s-IgA secretion rate
remained unchanged. There was a 37% reduction in s-IgA:osmolality postexercise (p
< .05), and salivary cortisol increased by 68% (p < .05). There was no effect of FED
vs. FAST on these salivary responses. The s-IgA concentration, secretion rate, and
osmolality were found to be significantly lower in women than in men throughout the
exercise protocol (p < .05); however, there was no difference between genders in
saliva flow rate, s-IgA:osmolality ratio, or cortisol. These data demonstrate that a fed
or fasted state 2 hr before exercise does not influence resting s-IgA or the response to
prolonged cycling. Furthermore, these results show lower levels of s-IgA and osmolality
in women than in men at rest.
2012-10-05 10:28:41
Salivary immunoglobulin A
Nutritional status
Exercise
Gender
Saliva flow rate
Medical and Health Sciences not elsewhere classified