%0 Journal Article %A Svendsen, Ida %A Killer, Sophie C. %A Carter, James %A Randell, Rebecca K. %A Jeukendrup, A.E. %A Gleeson, Michael %D 2016 %T Impact of intensified training and carbohydrate supplementation on immunity and markers of overreaching in highly trained cyclists %U https://repository.lboro.ac.uk/articles/journal_contribution/Impact_of_intensified_training_and_carbohydrate_supplementation_on_immunity_and_markers_of_overreaching_in_highly_trained_cyclists/9628214 %2 https://repository.lboro.ac.uk/ndownloader/files/17277077 %K Overreaching %K Cytokine %K Lymphocyte %K Interleukin %K Cortisol %K ACTH %K Medical and Health Sciences not elsewhere classified %X PURPOSE. To determine effects of intensified training (IT) and carbohydrate supplementation on overreaching and immunity. METHODS. In a randomized, double-blind, crossover design, 13 male cyclists (age 25 ± 6 years, (Formula presented.) 72 ± 5 ml/kg/min) completed two 8-day periods of IT. On one occasion, participants ingested 2 % carbohydrate (L-CHO) beverages before, during and after training sessions. On the second occasion, 6 % carbohydrate (H-CHO) solutions were ingested before, during and after training, with the addition of 20 g of protein in the post-exercise beverage. Blood samples were collected before and immediately after incremental exercise to fatigue on days 1 and 9. RESULTS. In both trials, IT resulted in decreased peak power (375 ± 37 vs. 391 ± 37 W, P < 0.001), maximal heart rate (179 ± 8 vs. 190 ± 10 bpm, P < 0.001) and haematocrit (39 ± 2 vs. 42 ± 2 %, P < 0.001), and increased plasma volume (P < 0.001). Resting plasma cortisol increased while plasma ACTH decreased following IT (P < 0.05), with no between-trial differences. Following IT, antigen-stimulated whole blood culture production of IL-1α was higher in L-CHO than H-CHO (0.70 (95 % CI 0.52–0.95) pg/ml versus 0.33 (0.24–0.45) pg/ml, P < 0.01), as was production of IL-1β (9.3 (95 % CI 7–10.4) pg/ml versus 6.0 (5.0–7.8) pg/ml, P < 0.05). Circulating total leukocytes (P < 0.05) and neutrophils (P < 0.01) at rest increased following IT, as did neutrophil:lymphocyte ratio and percentage CD4+ lymphocytes (P < 0.05), with no between-trial differences. CONCLUSION. IT resulted in symptoms consistent with overreaching, although immunological changes were modest. Higher carbohydrate intake was not able to alleviate physiological/immunological disturbances. %I Loughborough University