The effects of acute dopamine reuptake inhibition on performance
Bart Roelands
Hiroshi Hasegawa
Phil Watson
Maria F. Piacentini
Luk Buyse
Guy De Schutter
Romain Meeusen
2134/11375
https://repository.lboro.ac.uk/articles/journal_contribution/The_effects_of_acute_dopamine_reuptake_inhibition_on_performance/9628922
Introduction: Acute bupropion (BUP; dopamine/noradrenaline reuptake inhibitor)
administration significantly improved time trial performance and increased core
temperature in the heat (30°C). Purpose: The present study was performed to examine
the effect of a dopaminergic reuptake inhibitor on exercise capacity and
thermoregulation during prolonged exercise in temperate and warm conditons.
Methods: Eight healthy well-trained male cyclists participated in this study. Subjects
ingested either a placebo (PLAC; lactose; 20mg) or Ritalin (RIT; methylphenidate
(MPH); 20mg) one hour before the start of exercise in temperate (18°C) or warm (30°C)
conditions and cycled for 60 min at 55% Wmax, immediately followed by a time trial
(TT; pla18 and rit18; pla30 and rit30) to measure exercise performance. Results: Ritalin
did not influence TT performance at 18oC (P=0.397). TT was completed 16% faster in
rit30 (38.1±6.4min) than in pla30 (45.4±7.3min; p=0.049). Power output was higher in
rit30, compared to pla30 (p<0.05). In the heat Tcore was significantly higher at rest
(p=0.009), at the start of exercise and throughout rit30 (p<0.05). Throughout rit30 heart
rates were significantly higher (p<0.05). Prolactin concentrations decreased after one
hour cycling in 18°C (p=0,036) and at rest in 30°C (p=0,007) after RIT administration.
Conclusions: These results show that RIT has a clear ergogenic effect that was not
apparent in 18°C. The combination of a dopamine reuptake inhibitor and exercise in the
heat clearly improved performance and appeared to increase metabolic heat production,
suggesting an important role for dopamine in the fatigue process.
2013-01-09 09:52:37
Central fatigue
Methylphenidate
Exercise
Warm environmental temperature
Medical and Health Sciences not elsewhere classified