Dulson, Deborah K. Bishop, Nicolette Effect of a high and low dose of caffeine on human lymphocyte activation in response to antigen stimulation This study investigated the effect of caffeine on antigen-stimulated lymphocyte activation. Six males rested for 3.5 h after ingesting 0 (PLA), 2, or 6 (6CAF) mg·kg−1 body mass of caffeine. The number of antigen-stimulated NK CD69+ cells increased in 6CAF at 1 h compared with PLA (P = 0.021). Caffeine did not influence the number of antigen-stimulated CD69+ T cells or the geometric mean fluorescence intensity expression of CD69 on antigen-stimulated lymphocytes, suggesting caffeine has little effect on antigen-stimulated lymphocyte activation. Caffeine;Methylxanthine;Immune;CD69;Lymphocytes;T cell;NK cell;Medical and Health Sciences not elsewhere classified 2016-03-08
    https://repository.lboro.ac.uk/articles/journal_contribution/Effect_of_a_high_and_low_dose_of_caffeine_on_human_lymphocyte_activation_in_response_to_antigen_stimulation/9628958