2134/15380 Louisa Edwards Louisa Edwards Christopher Ring Christopher Ring David McIntyre David McIntyre John B. Winer John B. Winer Una Martin Una Martin Cutaneous sensibility and peripheral nerve function in patients with unmedicated essential hypertension Loughborough University 2014 Cutaneous sensory thresholds Essential hypertension Median nerve Nerve conduction velocity Sensory action potential amplitudes Medical and Health Sciences not elsewhere classified 2014-07-29 13:03:52 Journal contribution https://repository.lboro.ac.uk/articles/journal_contribution/Cutaneous_sensibility_and_peripheral_nerve_function_in_patients_with_unmedicated_essential_hypertension/9629564 Sensorimotor deficits in patients with essential hypertension may be due to impaired nerve function. Cutaneous sensory thresholds, median nerve sensory and motor conduction velocities, andmedian nerve sensory action potential amplitudes were assessed in 30 patients with unmedicated essential hypertension and 29 normotensives. Cutaneous sensory thresholds were higher and sensory action potential amplitudes smaller in hypertensives than normotensives whereas sensory and motor nerve conduction velocities did not differ between groups. These data suggest that hypertension may reduce the number of active sensory nerve fibers without affecting myelination. Sensory action potential amplitudes were inversely related to cutaneous sensory thresholds, suggesting that subclinical axonal neuropathy of sensory afferents may help account for perceptual deficits that characterize hypertension.