Thesis-2017-Myatt.pdf (910.06 MB)
A fundamental study of the primary atomisation mechanism and aerosol plume development of the pressurised metered dose inhaler
thesis
posted on 2017-11-22, 16:01 authored by Ben MyattThe pressurised metered dose inhaler (pMDI) is the most popular device for delivery of inhaled therapeutic aerosols to the lungs for treatment of asthma and COPD. One significant weakness of the pMDI is the high level of oropharyngeal deposition leading to low drug delivery efficiency. With the increasing prevalence of respiratory diseases and desire to improve the efficacy of drug delivery a deeper fundamental understanding of the atomisation process and aerosol plume physics is required. This thesis reports the findings of experimental studies using optical diagnostic techniques to investigate the internal flow processes and to characterise the spray plume of pharmaceutically relevant formulations. A new experimental protocol for laboratory measurements of pMDIs has been developed. [Continues.]
Funding
Chiesi Farmaceutici SpA
History
School
- Mechanical, Electrical and Manufacturing Engineering
Publisher
Loughborough UniversityRights holder
© B.J. MyattPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2017Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.Language
- en
Supervisor(s)
Graham Hargrave ; Henk Versteeg ; Edward LongQualification name
- PhD
Qualification level
- Doctoral
Administrator link
Usage metrics
Keywords
Pressurised Metered Dose InhalerpMDIMetered Dose InhalerInhalerPhase Doppler AnomometryPDAParticle Image VelocimetryPIVAtomisationAtomizationAtomisation mechanismAtomization mechanismAerosol plume developmentHFA134HFA227HFA134-ethanolHFA134/ethanolAsthmaCOPDOptical diagnosticsOptical diagnostic techniquesFlow visualisationInternal flow visualisationExternal flow visualisationSchlierenSchlieren imagingSpray plumeAerosolAerosol plumeHigh speed imagingPlume characterisationSpray characterisationDroplet sizeVelocitySpeedMechanical Engineering not elsewhere classified
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC