RESUBMITTED_FINAL_END.pdf (1.55 MB)
A validated model of GAG deposition, cell distribution, and growth of tissue engineered cartilage cultured in a rotating bioreactor
journal contribution
posted on 2013-10-15, 14:33 authored by Nikolay Nikolaev, B. Obradovic, Hendrik Versteeg, G. Lemon, David WilliamsThe purpose of this article is to review the different strategies for the delivery of plasmid DNA (pDNA)-based gene therapy. Plasmids are extrachromosomal DNA capable of being transmitted from cell to cell. They are supercoiled, circular covalently closed (ccc) strands of DNA capable of replication independently of host DNA and ranging from 5 to 400 kilo base pairs (kb) in size, depending on the size of the therapeutic gene insert.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Citation
NIKOLAEV, N.I. ... et al, 2010. A validated model of GAG deposition, cell distribution, and growth of tissue engineered cartilage cultured in a rotating bioreactor. Biotechnology and Bioengineering, 105 (4), pp.842-853.Publisher
© John Wiley and SonsVersion
- SMUR (Submitted Manuscript Under Review)
Publication date
2010Notes
This is the pre-peer reviewed version of the article which has been published in final form at: http://dx.doi.org/10.1002/bit.22581ISSN
0006-3592Publisher version
Language
- en