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Abnormalities of saccadic eye movements in dementia due to Alzheimer’s disease and mild cognitive impairment
journal contribution
posted on 2019-08-07, 10:13 authored by Thomas DW Wilcockson, Diako Mardanbegi, Baiqiang Xia, Simon Taylor, Pete Sawyer, Hans W Gellersen, Ira Leroi, Rebecca Killick, Trevor J CrawfordBackground: There is increasing evidence that people in the early stages of Alzheimer’s disease (AD) have subtle impairments in cognitive inhibition that can be detected by using relatively simple eye-tracking paradigms, but these subtle impairments are often missed by traditional cognitive assessments. People with mild cognitive impairment (MCI) are at an increased likelihood of dementia due to AD. No study has yet investigated and contrasted the MCI subtypes in relation to eye movement performance. Methods: In this work we explore whether eye-tracking impairments can distinguish between patients with the amnesic and the non-amnesic variants of MCI. Participants were 68 people with dementia due to AD, 42 had a diagnosis of aMCI, and 47 had a diagnosis of naMCI, and 92 age-matched cognitively healthy controls. Results: The findings revealed that eye-tracking can distinguish between the two forms of MCI. Conclusions: The work provides further support for eye-tracking as a useful diagnostic biomarker in the assessment of dementia.
Funding
EPSRC project EP/M006255/1 Monitoring Of Dementia using Eye Movements (MODEM)
Sir John Fisher Foundation
History
School
- Sport, Exercise and Health Sciences
Published in
AgingVolume
11Issue
15Pages
5389 - 5398Publisher
Impact Journals, LLCVersion
- VoR (Version of Record)
Rights holder
© Wilcockson et al.Publisher statement
This is an Open Access Article. It is published by Impact Journals, LLC under the Creative Commons Attribution 3.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/Acceptance date
2019-07-19Publication date
2019-08-02Copyright date
2019eISSN
1945-4589Publisher version
Language
- en
Depositor
Dr Thom WilcocksonUsage metrics
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