Foster_Acetaminophen (paracetamol) induces hypothermia during acute cold stress (accepted version).pdf (204.88 kB)
Acetaminophen (Paracetamol) induces hypothermia during acute cold stress
journal contribution
posted on 2018-02-02, 09:24 authored by Josh Foster, Alexis R. Mauger, Andrew Govus, David Hewson, Lee TaylorBackground Acetaminophen is an over-the-counter drug used to treat pain and fever, but it has also been shown to reduce core temperature (Tc) in the absence of fever.
However, this side effect is not well examined in humans, and it is unknown if the hypothermic response to acetaminophen
is exacerbated with cold exposure.
Objective To address this question, we mapped the thermoregulatory responses to acetaminophen and placebo administration during exposure to acute cold (10 °C) and
thermal neutrality (25 °C).
History
School
- Design
Published in
Clinical Drug InvestigationVolume
37Issue
11Pages
1055 - 1065Citation
FOSTER, J. ...et al., 2017. Acetaminophen (Paracetamol) induces hypothermia during acute cold stress. Clinical Drug Investigation, 37(11), pp. 1055-1065.Publisher
© SpringerVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2017-08-01Notes
This is a post-peer-review, pre-copyedit version of an article published in Clinical Drug Investigation. The final authenticated version is available online at: https://doi.org/10.1007/s40261-017-0560-xISSN
1173-2563eISSN
1179-1918Publisher version
Language
- en