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Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing

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posted on 2016-02-23, 13:40 authored by Hadi Hajiali, Maria Summa, Debora Russo, Andrea Armirotti, Virgilio Brunetti, Rosalia Bertorelli, Athanassia Athanassiou, Elisa MeleElisa Mele
One of the current challenges in wound care is the development of multifunctional dressings that can both protect the wound from external agents and promote the regeneration of the new tissue. Here, we show the combined use of two naturally derived compounds, sodium alginate and lavender essential oil, for the production of bioactive nanofibrous dressings by electrospinning, and their efficacy for the treatment of skin burns induced by midrange ultraviolet radiation (UVB). We demonstrate that the engineered dressings reduce the risk of microbial infection of the burn, since they stop the growth of Staphylococcus aureus. Furthermore, they are able to control and reduce the inflammatory response that is induced in human foreskin fibroblasts by lipopolysaccharides, and in rodents by UVB exposure. In particular, we report a remarkable reduction of pro-inflammatory cytokines when fibroblasts or animals are treated with the alginate-based nanofibers. The down-regulation of cytokines production and the absence of erythema on the skin of the treated animals confirm that the here described dressings are promising as advanced biomedical devices for burn management.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Journal of Materials Chemistry B

Volume

4

Issue

9

Pages

1686 - 1695

Citation

HAJIALI, H. ...et al., 2016. Alginate-lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing. Journal of Materials Chemistry B, 4 (9), pp. 1686-1695.

Publisher

© Royal Society of Chemistry

Version

  • AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

2016-02-03

Publication date

2016-02-04

Notes

This paper was accepted for publication in the journal Journal of Materials Chemistry B and the definitive published version is available at http://dx.doi.org/10.1039/C5TB02174J

ISSN

2050-750X

eISSN

2050-7518

Language

  • en

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