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An alkylation route to carbo- and heteroaromatic amino acids

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journal contribution
posted on 2009-03-20, 14:55 authored by Ray Jones, Didier J.C. Berthelot, James N. Iley
Amino acids carrying aromatic carbo- and heterocycles in the side chain, such as naphthyl-, biphenyl- and pyridylalanines, have been prepared by alkylation of a glycine enolate with a haloalkyl carbocycle or heterocycle, with enantiomeric excess up to 87% using the ephedrine amide protocol.

History

School

  • Science

Department

  • Chemistry

Citation

JONES, R.C.F., BERTHELOT, D.J.C. and ILEY, J.N., 2007. An alkylation route to carbo- and heteroaromatic amino acids. ARKIVOC, 2007 (xi), pp. 73-84

Publisher

© ARKAT USA, Inc.

Version

  • VoR (Version of Record)

Publication date

2007

Notes

This is an article that was published in the journal, ARKIVOC [© ARKAT USA]. It is also available at; http://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/

ISSN

1424-6376

Language

  • en