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Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom
journal contribution
posted on 2014-06-27, 12:55 authored by Anant M. Ghelani, Ash Samanta, Adrian C. Jones, Sarabjit MastanaSarabjit MastanaGenetic associations of TNFR2, VDR (Bsm I and Fok I), A2M, GSTT , GSTM and ACE in South Asian and Caucasian patients with rheumatoid arthritis (RA) were assessed in this study. DNA samples from South Asians (134 cases, 149 controls) and Caucasians (137 cases, 150 controls) from the East Midlands of the United Kingdom were genotyped for seven polymorphisms. All cases were rheumatoid-factor positive. Significant genetic associations were observed with TNFR2 R-R (OR = 3.16, CI 1.20-9.26, P < 0.05), A2M 1-1 (OR = 2.09, CI 1.21-3.64, P < 0.05) and GST Tnull (OR = 1.97, CI 1.07-3.68, P < 0.05) among Caucasian patients. In South Asians, VDR Bsm I B-B genotype (OR = 2.08, CI 1.23-3.52, P < 0.05), A2M 2-2 genotype (OR = 3.99, CI 1.19-17.18, P < 0.05), and GST Tnull genotype (OR = 2.81, CI 1.40-5.77, P < 0.002) genotypes were associated with RA. In the majority of cases, recessive and multiplicative modes of inheritance explained the observed associations. This study demonstrates that ethnicity affects the genetic associations in RA. © 2010 Springer-Verlag.
History
School
- Sport, Exercise and Health Sciences
Published in
Rheumatology InternationalVolume
31Issue
10Pages
1355 - 1361Citation
GHELANI, A.M. ... et al, 2011. Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom. Rheumatology International, 31 (10), pp. 1355 - 1361Publisher
© Springer-VerlagVersion
- VoR (Version of Record)
Publication date
2011Notes
This article is closed access.ISSN
0172-8172eISSN
1437-160XPublisher version
Language
- en