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Cellular senescence: immunosurveillance and future immunotherapy

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journal contribution
posted on 19.02.2018 by Dominick Burton, Alexandra Stolzing
In response to persistent DNA damage, induction into cell senescence promotes an immunogenic program which facilitates immune clearance of these damaged cells. Under physiological conditions, senescent cells can activate both innate and adaptive immune responses, functioning to maintain tissue homeostasis. In addition, emerging findings suggest that programmed induction of cell senescence may be important for regulating reproductive processes, partly facilitated by immune clearance. However, likely owing to ageing of the immune system, a failure to eliminate senescent cells can contribute to their persistence in tissues, leading to the development and progression of age-related diseases. Such immune failure may in part be due to activation of the senescence program in immune cells, leading to their dysfunction. Furthermore, senescent cells under certain biological contexts have been shown to instead promote immune suppression, a response that may reflect differences between an acute verses chronic senescent phenotype. In this review, we provide an overview of the research to date concerning senescence immunosurviellance, including a focused discussion on the mechanisms by which macrophages may recognise senescent cells. Senescence immunotherapy strategies as an alternative to senolytics for the removal of senescent cells will also be discussed.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Ageing Res Rev

Citation

BURTON, D.G.A. and STOLZING, A., 2018. Cellular senescence: immunosurveillance and future immunotherapy. England, Ageing Research Reviews, 43, pp. 17-25.

Publisher

© Elsevier

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

02/02/2018

Publication date

2018-02-07

Notes

This paper was accepted for publication in the journal Ageing Research Reviews and the definitive published version is available at https://doi.org/10.1016/j.arr.2018.02.001

eISSN

1872-9649

Other identifier

S1568-1637(18)30011-4

Language

en

Location

England

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