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Characterization of biodegradable poly(l‐lactide) tube over accelerated degradation
journal contribution
posted on 2020-03-30, 08:10 authored by Raasti Naseem, Liguo Zhao, Senthil K. Eswaran, Helen WillcockHelen WillcockThe next‐generation bioresorbable polymeric stents are undergoing continual research and development, especially how to control and optimize their degradation behaviors. The aim of this paper is to study the properties of a poly(l‐lactide) (PLLA) tube over accelerated degradation in vitro. Spherical nanoindentation was particularly adopted to measure the mechanical properties of PLLA tube; while differential scanning calorimetry and gel permeation chromatography were used for crystallinity and molecular weight measurements. Overall, the material degradation was captured by the local stress‐strain response obtained with spherical nanoindentation, and further confirmed with chemical analyses. The results are particularly useful for development of bioresorbable polymeric stents with improved performance.
Funding
British Heart Foundation (Grant reference: FS/15/21/31424; Title: Towards controlling the mechanical performance of polymeric bioresorbable vascular stent during biodegradation)
History
School
- Mechanical, Electrical and Manufacturing Engineering
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Materials
Published in
Polymer Engineering and ScienceVolume
60Issue
7Pages
1430 - 1436Publisher
Wiley Periodicals, Inc. on behalf of Society of Plastics EngineersVersion
- VoR (Version of Record)
Rights holder
© The AuthorsPublisher statement
This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Acceptance date
2020-03-27Publication date
2020-04-08Copyright date
2020ISSN
0032-3888eISSN
1548-2634Publisher version
Language
- en
Depositor
Prof Liguo Zhao. Deposit date: 27 March 2020Usage metrics
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