Accepted_J Biomech.pdf (3.03 MB)
Computational analysis of mechanical stress-strain interaction of a bioresorbable scaffold with blood vessel
journal contribution
posted on 2016-06-21, 12:18 authored by Alessandro Schiavone, C. Abunassar, S. Hossainy, Liguo ZhaoCrimping and deployment of bioresorbable polymeric scaffold, Absorb, were modelled using finite element method, in direct comparison with Co-Cr alloy drug eluting stent, Xience V. Absorb scaffold has an expansion rate lower than Xience V stent, with a less outer diameter achieved after
balloon deflation. Due to the difference in design and material properties, Absorb also shows a higher recoiling than Xience V, which suggests that additional post-dilatation is required to achieve
effective treatment for patients with calcified plaques and stiff vessels. However, Absorb scaffold induces significantly lower stresses on the artery-plaque system, which can be clinically beneficial. Eccentric plaque causes complications to stent deployment, especially non-uniform vessel expansion. Also the stress levels in the media and adventitia layers are considerably higher for the plaque with high eccentricity, for which the choice of stents, in terms of materials and designs, will be of paramount importance. Our results imply that the benefits of Absorb scaffolds are amplified
in these cases.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Journal of BiomechanicsCitation
SCHIAVONE, A. ...et al., 2016. Computational analysis of mechanical stress-strain interaction of a bioresorbable scaffold with blood vessel. Journal of Biomechanics, 49 (13), pp. 2677-2683.Publisher
© ElsevierVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2016-06-01Publication date
2016-06-06Notes
This paper was accepted for publication in the journal Journal of Biomechanics and the definitive published version is available at http://dx.doi.org/10.1016/j.jbiomech.2016.05.035ISSN
1873-2380Publisher version
Language
- en