1-s2.0-S0140197119301289-main.pdf (204.14 kB)
Depressive symptoms at age 9–13 and chronic disabling fatigue at age 16: A longitudinal study
journal contribution
posted on 2020-02-11, 10:11 authored by Simon M Collin, Tom Norris, Carol Joinson, Maria E Loades, Glyn Lewis, Stephen A Stansfeld, Esther CrawleyIntroduction
We investigated whether depressive symptoms at ages 9–13 years were associated with chronic disabling fatigue (CDF) at age 16 among children in the Avon Longitudinal Study of Parents & Children (ALSPAC) birth cohort.
Methods
Depressive symptoms at ages 9, 10, 11, 12, and 13 years were defined as a child- or parent-completed Short Mood and Feelings Questionnaire (SMFQ) score ≥11 (range 0–26). SMFQ score was also analysed as a continuous exposure. Chronic disabling fatigue at 16 was defined as fatigue of ≥6 months' but <5 years’ duration which prevented school attendance or activities, for which other causes were not identified, and with a Chalder Fatigue Questionnaire score ≥19. Logistic regression was used with multiple imputation to correct for missing data bias. We performed sensitivity analyses in which children who had CDF and depressive symptoms at age 16 were reclassified as not having CDF.
Results
In fully adjusted models using imputed data (N = 13,978), depressive symptoms at ages 9, 11, and 13 years were associated with 2- to 3-fold higher odds of CDF at age 16. Each one-point increase in SMFQ score at ages 9, 10, 11, 12, and 13 years was associated with 6–11% higher odds of CDF at age 16. Depressive symptoms and continuous SMFQ scores at each age were not associated with CDF if the outcome was reclassified to exclude children with comorbid depressive symptoms at age 16.
Conclusions
Depressive symptoms at ages 9–13 were associated with chronic disabling fatigue at age 16, but causality is not certain.
Funding
UK Medical Research Council (grant MR/K020269/1)
The UK Medical Research Council and Wellcome (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC.
NIHR Senior Research Fellowship (SRF-2013-06-013)
National Institute for Health Research (Doctoral Research Fellowship, DRF-2016-09-021)
National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) North Thames at Bart's Health NHS Trust
History
School
- Sport, Exercise and Health Sciences
Published in
Journal of AdolescenceVolume
75Pages
123 - 129Publisher
Elsevier Ltd on behalf of The Foundation for Professionals in Services for Adolescents.Version
- VoR (Version of Record)
Rights holder
© The AuthorsPublisher statement
This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).Acceptance date
2019-07-30Publication date
2019-08-02Copyright date
2019ISSN
0140-1971Publisher version
Language
- en
Depositor
Dr Tom Norris. Deposit date: 10 February 2020Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC