RDD2018.Johnson1.pdf (205.49 kB)
Determination of density and surface tension in ethanol and HFA 134a mixtures
conference contribution
posted on 2018-06-18, 12:54 authored by R. Johnson, D.I. Lewis, Paul M. Young, Hendrik Versteeg, Graham HargraveGraham HargraveRecent publications of a transient aerodynamic atomization model have highlighted saturated vapor pressure, density, viscosity and surface tension as key properties governing pressurized metered dose inhaler (pMDI) droplet size1, 2, 3. Pharmaceutical pMDI formulations widely use mixtures of propellant and excipients, such as ethanol, but mixing rules for the aforementioned properties are not available in the literature. Hence, composition-dependent surface tension and density were experimentally determined for ethanol-HFA 134a mixtures. The expressions presented of density and surface tension are advantageous to understanding transient flows inside the actuator and atomization of pMDI formulations containing ethanol as a co-solvent 2.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Respiratory Drug Delivery 2018Volume
2Pages
467 - 472 (6)Citation
Johnson R, Lewis DI, Young PM, Versteeg HK, Hargrave G: Determination of Density and Surface Tension in Ethanol and HFA 134a Mixtures. In Respiratory Drug Delivery 2018. Volume 2, Edited by Dalby RN, Peart J, Suman, J, Young PM, Traini D. DHI Publishing; River Grove, IL: 2018: 467-472.Version
- NA (Not Applicable or Unknown)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2018Notes
Provided with permission from Respiratory Drug Delivery 2018, Virginia Commonwealth University and RDD Online.Publisher version
Language
- en