Development of methods for cellobiose and mannitol in urine

Differential absorption of probe molecules, such as cellobiose and mannitol, has been used for the diagnosis and monitoring of patients with coeliac disease. After an oral dose of cellobiose and mannitol, the patient collects all urine passed for 5 hours. The urinary recoveries of cellobiose and mannitol are measured and expressed as a ratio which gives an indication of intestinal permeability. [Continues.]