Development of Novel Drug Formulation Using Microfluidic Device.pdf (389.46 kB)
Development of novel drug formulation using microfluidic device
poster
posted on 2012-07-18, 15:16 authored by Ekanem E. Ekanem, Yuk Yeung Shiu, Zhandos Tauanov, Lav Sharma, Hamed Shahmohamadi, John V. Henry, Diganta Bhusan Das, Goran VladisavljevicGoran VladisavljevicPoster introduction: Biosorbable poly(lactic acid) (PLA) microspheres have been used for
controlled drug release, as ultrasound contrast agents, for cell cultivation
in tissue engineering, fabrication of scaffolds, composite coatings, etc.
Coherent PLA particles can be fabricated via single emulsion route. First,
PLA is dissolved in a volatile organic solvent (DCM) and this solution is
emulsified in an aqueous surfactant solution. In the next stage, the
resultant droplets are solidified by evaporation of solvent. Porous PLA
particles can be produced via W/O/W emulsion route, where first, an
inner water phase is dispersed in a mixture of PLA and DCM in the
presence of oil-soluble surfactant form a W/O emulsion. This emulsion is
then dispersed drop-wise into an aqueous surfactant solution to form a
W/O/W emulsion. W/O particles are formed by evaporation of DCM.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Citation
EKANEM, E.E. ... et al, 2012. Development of novel drug formulation using microfluidic device. 11th UK Particle Technology Forum 2012 "Formulating with particles", Loughborough University, 4th-5th April.Publication date
2012Notes
This is a conference poster.Publisher version
Language
- en