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Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry
journal contributionposted on 17.12.2013 by Robert W. Smith, Jim Reynolds, Sze-Ling Lee, Colin Creaser
Any type of content formally published in an academic journal, usually following a peer-review process.
Thermal desorption has been combined with field asymmetric waveform ion mobility spectrometry and mass spectrometry for the rapid, direct analysis of isobaric potentially genotoxic impurities (PGIs) in a surrogate active pharmaceutical ingredient. FAIMSselected PGIs were detected with limits of quantification <0.2 ppm, below the threshold of toxicological concern, with %RSD <8.4%, at the 1 ppm level.