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Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry

journal contribution
posted on 17.12.2013 by Robert W. Smith, Jim Reynolds, Sze-Ling Lee, Colin Creaser
Thermal desorption has been combined with field asymmetric waveform ion mobility spectrometry and mass spectrometry for the rapid, direct analysis of isobaric potentially genotoxic impurities (PGIs) in a surrogate active pharmaceutical ingredient. FAIMSselected PGIs were detected with limits of quantification <0.2 ppm, below the threshold of toxicological concern, with %RSD <8.4%, at the 1 ppm level.

History

School

  • Science

Department

  • Chemistry

Citation

SMITH, R.W. ... et al, 2013. Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry. Analytical Methods, 5 (16), pp.3799-3802.

Publisher

© Royal Society of Chemistry

Version

VoR (Version of Record)

Publication date

2013

Notes

This article is closed access.

ISSN

1759-9660;1759-9679

Language

en

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