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Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry
journal contribution
posted on 2013-12-17, 11:46 authored by Robert W. Smith, Jim ReynoldsJim Reynolds, Sze-Ling Lee, Colin CreaserThermal desorption has been combined with field asymmetric
waveform ion mobility spectrometry and mass spectrometry for the
rapid, direct analysis of isobaric potentially genotoxic impurities
(PGIs) in a surrogate active pharmaceutical ingredient. FAIMSselected
PGIs were detected with limits of quantification <0.2 ppm,
below the threshold of toxicological concern, with %RSD <8.4%, at
the 1 ppm level.
History
School
- Science
Department
- Chemistry
Citation
SMITH, R.W. ... et al, 2013. Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry. Analytical Methods, 5 (16), pp.3799-3802.Publisher
© Royal Society of ChemistryVersion
- VoR (Version of Record)
Publication date
2013Notes
This article is closed access.ISSN
1759-9660;1759-9679Publisher version
Language
- en