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Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes

journal contribution
posted on 2015-09-15, 13:44 authored by Kathryn L. Gempf, Stephen ButlerStephen Butler, Alexander M. Funk, David Parker
A cysteine-selective tagging method in water is reported, based on rapid displacement of a pyridyl nitro-substituent in simple pyridines and lanthanide complexes. The conjugation reaction creates a short link between the tag and peptide, holding the peptide closer to the Ln3+ ion and with reduced flexibility compared to existing methods.

Funding

We thank the ERC for support (FCC 266804).

History

School

  • Science

Department

  • Chemistry

Published in

CHEMICAL COMMUNICATIONS

Volume

49

Issue

80

Pages

9104 - 9106 (3)

Citation

GEMPF, K.L. ... et al, 2013. Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes. Chemical Communications, 49 (80), pp. 9104 - 9106.

Publisher

© The Royal Society of Chemistry

Version

  • VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2013

Notes

This article is closed access.

ISSN

1359-7345

Language

  • en

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