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ENPP1 K121Q functional variant enhances susceptibility to insulin resistance and dyslipidemia with metabolic syndrome in Asian Indians
journal contribution
posted on 2018-11-30, 15:11 authored by Gurjit Kaur Bhatti, Sumanpreet Kaur, Rajesh Vijayergiya, Sanjay Kumar Bhadada, Sarabjit MastanaSarabjit Mastana, Bhupinder Singh, Jasvinder Singh BhattiBackground: Ectonucleotide pyrophosphatase/phosphodiesterase1
(ENPP1/PC-1) is a key modulator of the insulin signaling
pathway, and its common variant, K121Q, increases
the susceptibility to diabetes and cardiovascular diseases.
Objectives: The main objective of the present study was to
investigate the association of ENPP1 K121Q polymorphism
with the pathophysiology of metabolic syndrome (MetS) in
a north Indian population. Methods: A total of 567 participants
(303 MetS subjects and 264 healthy controls) were examined
for ENPP1 genotypes and various clinical parameters,
including body mass index (BMI), waist circumference
(WC), systolic and diastolic blood pressures (SBP/DBP), fasting
blood glucose (FBG), cholesterol, triglycerides (TG), highdensity
lipoprotein, and insulin. Genotyping was performed
using polymerase chain reaction-restriction fragment length
polymorphism (PCR-RFLP). Statistical analysis of the data
was done using SPSS. Results: Significant increases in BMI,
WC, SBP, DBP, FBG, TG, low-density lipoprotein, insulin, and
Homeostasis Model Assessment of insulin resistance (HOMAIR)
and of beta-cell function (HOMA-BF) were observed in
MetS patients compared to healthy controls. Logistic regression
analysis of data demonstrated a nonsignificant association
of QQ and KQ+QQ genotypes with increased risk of
MetS (OR [95% CI], 1.583 [0.455–5.507], p = 0.470 for QQ genotypes
and 1.097 [0.784–1.540], p = 0.587 for KQ+QQ genotypes).
Moreover, MetS subjects carrying Q alleles had significantly
higher levels of TG, insulin, body fat percentage,
and insulin resistance as evident by higher values of HOMAIR.
Conclusions: We conclude that ENPP1 K121Q functional
variant enhances susceptibility to insulin resistance and dyslipidemia
in MetS subjects of an Asian Indian population.
Funding
University Grant Commission, Government of India.
History
School
- Sport, Exercise and Health Sciences
Published in
International Journal of Diabetes and MetabolismVolume
21Pages
8 - 15Citation
BHATTI, G.K. ... et al., 2018. ENPP1 K121Q functional variant enhances susceptibility to insulin resistance and dyslipidemia with metabolic syndrome in Asian Indians. International Journal of Diabetes and Metabolism, 21, pp. 8-15.Publisher
© the Authors. Published by Karger PublishersVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2018-07-01Publication date
2018-08-31Notes
This is an Open Access Article. It is published by Karger under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/ISSN
1606-7754Publisher version
Language
- en