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EPA DHA dietary supplementation attenuates exercise induced bronchoconstriction in physically active asthmatic males.pdf (598.66 kB)

EPA/DHA dietary supplementation attenuates exercise-induced bronchoconstriction in physically active asthmatic males

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posted on 2016-07-01, 09:02 authored by Aishwarya Kumar, Sarabjit MastanaSarabjit Mastana, Martin Lindley
Asthma is a common and prevalent health problem, globally affecting over 300 million individuals. Observational and intervention studies have shown beneficial effects of omega-3 [Eicosapentaenoic Acid (EPA) and Docosahexaenoic acid (DHA)] on asthma and exercise-induced bronchoconstriction (EIB). Due to health side effects with pharmacological medication, use of complementary therapies including omega-3 supplementation is gaining impetus. A double-blinded randomised crossover pilot study with 3 weeks of supplementation (3.2 g EPA and 2.2 g DHA or placebo) was conducted to assess the effect of omega-3 supplementation in physically active males with EIB (n = 9, 21 ± 0.9 years, Forced Expiratory Volume in 1-s/Forced Vital Capacity (FEV1/FVC) = 77 ± 1.4). At the start of study, participants showed abnormal lung function, typical drop of >10% in their FEV1 following exercise-challenge tests; elevated levels of Exhaled-breath Nitric oxide, FeNO (>40 ppb). The 3-week supplementation resulted in a significant improvement in post-exercise pulmonary function (PF) (<10% drop in post-exercise FEV1/FVC), supported by significant reduction in serum IL-6 levels (37% reduction). Although no significant changes were observed for Peripheral Blood Mononuclear Cell (PBMC) total lipid composition for EPA/DHA, non-significant increase in total PBMC EPA/DHA with reduction in omega-6 fatty acid (Arachidonic Acid) was observed. This pilot study shows a beneficial effect of 3 weeks of omega-3 supplementation on PF for EIB-participants.

History

School

  • Sport, Exercise and Health Sciences

Published in

Cogent Medicine

Volume

3

Issue

1

Citation

KUMAR, A., MASTANA, S.S. and LINDLEY, M.R., 2016. EPA/DHA dietary supplementation attenuates exercise-induced bronchoconstriction in physically active asthmatic males. Cogent Medicine, 3:1172696

Publisher

© The Authors. Published by Taylor & Francis

Version

  • VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Acceptance date

2016-03-23

Publication date

2016

Notes

This is an Open Access Article. It is published by Taylor and Francis under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

ISSN

2331-205X

Language

  • en

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